The ROR1 pseudokinase diversifies signaling outputs in MET-addicted cancer cells
نویسندگان
چکیده
منابع مشابه
Tumor and Stem Cell Biology Ror1 Is a Pseudokinase That Is Crucial for Met-Driven Tumorigenesis
The human kinome includes Ror1, a poorly characterized orphan receptor. Here we report the findings of an investigation of Ror1 contributions to cancer, undertaken through an integrated screening of 43 cancer cell lines where we measured protein expression, tyrosine phosphorylation, and growth response following RNAimediated Ror1 suppression. Ror1 was expressed in approximately 75% of the cance...
متن کاملROR1 is a pseudokinase that is crucial for MET-driven tumorigenesis
The human kinome includes Ror1, a poorly characterized orphan receptor. Here we report the findings of an investigation of Ror1 contributions to cancer, undertaken through an integrated screening of 43 cancer cell lines where we measured protein expression, tyrosine phosphorylation, and growth response following RNAi-mediated Ror1 suppression. Ror1 was expressed in approximately 75% of the canc...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2014
ISSN: 0020-7136
DOI: 10.1002/ijc.28879